1 Lip-drying mistake: Medication
If a medication can cause dry mouth, it can cause dry, chapped lips, experts warn. The list is long and includes many over-the-counter and prescription medications including anti-depressants, antihistamines, anti-anxiety medications, decongestants, muscle relaxants, and pain medications, according to the Mayo Clinic. Ask your doctor or pharmacist whether your meds may be causing your dry, chapped lips. He or she will likely recommend coping strategies including the use of a moisturizing lip balm.